Preparation and Administration of Drugs

In most hospitals the reconstitution and preparation of complex drugs takes place in centralized units typically in a controlled environment with experienced staff. When preparing intravenous drugs there are key elements that need to be taken into account:

  • accurate dose and concentration
  • sterility
  • stability
  • occupational exposure

Adhering to guidelines and recommendations is important but may not be sufficient. The preparation and administration of toxic drugs is sometimes more complex and the risk of errors and system failures could result in harmful outcome for the patient.

The prevalence of medication errors associated with drugs is not exactly known, but incorrect usage of these drugs can cause serious harm for the patients. Therefore extra measures need to be taken to ensure patient safety and prevent medication errors.

Quality assurance systems are essential in order to dispense safe and accurate medications. Validation and verification systems are becoming more widely used, however DrugLog® provides real qualitative and quantitative testing that provides additional security for patients and staff.

Chemotherapy administration is an error-prone, high-risk process. The number and complexity of chemotherapy regimens are increasing steadily; most cytostatic and cytotoxic drugs have a narrow therapeutic range; dose adjustments are often needed; cancer patients are particularly susceptible to drug interactions; and medication delivery is an intricate process, with each step being a potentially significant source of error.

    • Prof. Pascal Odou
    • Centre Hospitalier Régional Universitaire , Lille, France
  • "It is well known that drug preparation in surgical units is considered at high risk, due to the stress and the multifaceted activities of medical staff. The aim of the research project on the DrugLog® system is to investigate the possibility to secure in routine the drug preparation in surgical units. To achieve this goal, firstly, we will realize a qualification for 13 drugs, such as heparin, adrenaline and different antibiotics commonly used in surgery based on the recommendations of the French Society of Pharmaceutical Science and Technology. Secondly, this qualification assay step will be completed by a selectivity and robustness study with similar drugs. Finally, if the two first steps are positive, the DrugLog® system will be used in the surgical unit to evaluate its capacity in routine use and its ability to avoid drug errors: syringe switch, wrong drugs or concentration errors"

    • Prof. Pascal Bonnabry
    • Director Hospital Pharmacy, Hôpitaux Universitaires de Genève, Geneva, Swizerland
  • "There is a need for simple quality control methods for individualized intravenous drugs that can be applied in the routine of a compounding unit and at the point of care. Innovative solutions have to be developed in collaboration between industrial companies and healthcare organizations. The results from the first technical and process validations of Pharmacolog’s product, DrugLog®, for cytostatic drugs at our department are promising. We will therefore continue the collaboration with Pharmacolog and evaluate the DrugLog® technology in the daily operation also for other drugs, and contribute to new technical developments in point of care solutions for individualized intravenous treatment control"

The DrugLog® technology

The core technology is based on absorption spectroscopy in the ultraviolet and visable light (UV-VIS) spectral range from 200 nm to 800 nm. Standard mini spectrometers and UV-VIS lamps are used in the system. In order to identify the drug to be tested a broad band spectral analysis of the liquid sample is made and matched against stored reference spectral data for calibrated drugs. Each drug to be compounded at a drug preparation unit shall be calibrated in advance and stored in the system as a reference. In this way generic drugs differences in spectral response can be identified which is used to automatically identify an accurate product. New drugs are continuously tested and calibrated for a full range of clinically used concentrations in the DrugLog® database.

DrugLog® has been tested and verified at hospital pharmacies in Sweden and Switzerland preparing cytostatic drugs and other non-toxic drugs like insulin, morphine and different antibiotics.

Download DrugLog® datasheet

System integration

DrugLog® has a built-in computer that can be connected to local networks for integrating with existing patient, treatment, drug prescription records, and other related databases.
The system is connected to internet via the local Wi-Fi network which enables remote service and support by Pharmacolog.

How it works

DrugLog is a combination of hardware and software that through a patented process can identify the drug being prepared and verify its concentration, prior to patient infusion.


The system is prepared and installed by the Pharmacolog staff. The physical installation is done in a few minutes and includes connection to the local Wi-Fi network. On that occasion your personnel will receive system training in order to efficiently operate the DrugLog system.


An individual calibration is needed for every drug the system shall be able to identify. This calibration must – per drug – consist of at least three measured spectra with three various concentrations. More measured data of other concentrations added to the calibration will increase the accuracy of the concentration determination. Your trained administrator will be able to perform the calibration procedure within a few minutes.

Daily use

The daily use of the system is intended for quality control of drugs compounded or diluted locally at the hospital. A 0.5 ml sample is extracted from the drug volume and inserted into the special cuvette. This is then placed in the cuvette holder of the DrugLog unit.

DrugLog can analyze the sample in 2 different modes.

The system will compare the measured spectrum with the available calibrated drugs in the database to identify and quantify the sample.

The operator enters the intended drug and its concentration prior to the analysis.
The system then compares the measured sample to verify that it coincides with the intended drug prescription, i.e. type and concentration.

Press a button and you have the answer in less than 1 second.

Statistics and Support

Over time, de-identified measurement data will be collected in a central database. The data will be an important source to create a drug calibration library, predictive instrument maintenance, glucose diluent degradation and product development.

This data will also be used to record and quantify drug preparation failure rates with the aim to develop preventative methods.


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