In most hospitals the reconstitution and preparation of complex drugs takes place in centralized units typically in a controlled environment with experienced staff. When preparing intravenous drugs there are key elements that need to be taken into account:
- accurate dose and concentration
- occupational exposure
Adhering to guidelines and recommendations is important but may not be sufficient. The preparation and administration of toxic drugs is sometimes more complex and the risk of errors and system failures could result in harmful outcome for the patient.
The prevalence of medication errors associated with drugs is not exactly known, but incorrect usage of these drugs can cause serious harm for the patients. Therefore extra measures need to be taken to ensure patient safety and prevent medication errors.
Quality assurance systems are essential in order to dispense safe and accurate medications. Validation and verification systems are becoming more widely used, however DrugLog® provides real qualitative and quantitative testing that provides additional security for patients and staff.
Chemotherapy administration is an error-prone, high-risk process. The number and complexity of chemotherapy regimens are increasing steadily; most cytostatic and cytotoxic drugs have a narrow therapeutic range; dose adjustments are often needed; cancer patients are particularly susceptible to drug interactions; and medication delivery is an intricate process, with each step being a potentially significant source of error.
- Prof. Pascal Odou
- Centre Hospitalier Régional Universitaire , Lille, France
- Prof. Pascal Bonnabry
- Director Hospital Pharmacy, Hôpitaux Universitaires de Genève, Geneva, Swizerland
The core technology is based on absorption spectroscopy in the ultraviolet and visable light (UV-VIS) spectral range from 200 nm to 800 nm. Standard mini spectrometers and UV-VIS lamps are used in the system. In order to identify the drug to be tested a broad band spectral analysis of the liquid sample is made and matched against stored reference spectral data for calibrated drugs. Each drug to be compounded at a drug preparation unit shall be calibrated in advance and stored in the system as a reference. In this way generic drugs differences in spectral response can be identified which is used to automatically identify an accurate product. New drugs are continuously tested and calibrated for a full range of clinically used concentrations in the DrugLog® database.
DrugLog® has been tested and verified at hospital pharmacies in Sweden and Switzerland preparing cytostatic drugs and other non-toxic drugs like insulin, morphine and different antibiotics.
DrugLog® has a built-in computer that can be connected to local networks for integrating with existing patient, treatment, drug prescription records, and other related databases. The system is connected to internet via the local Wi-Fi network which enables remote service and support by Pharmacolog.